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By National Research Council, Division on Engineering and Physical Sciences, Board on Environmental Studies and Toxicology, Committee on Toxicology, Subcommittee on Acute Exposure Guideline Levels

Super dangerous components (EHSs)² should be published by accident because of chemical spills, business explosions, fires, or injuries regarding railroad autos and vans transporting EHSs. staff and citizens in groups surrounding business amenities the place EHSs are synthetic, used, or saved and in groups alongside the nation's railways and highways are almost certainly susceptible to being uncovered to airborne EHSs in the course of unintentional releases or intentional releases by way of terrorists. Pursuant to the Superfund Amendments and Reauthorization Act of 1986, the U.S. Environmental security employer (EPA) has pointed out nearly four hundred EHSs at the foundation of acute lethality info in rodents. As a part of its efforts to improve acute publicity instruction degrees for EHSs, EPA and the company for poisonous components and illness Registry (ATSDR) in 1991 asked that the nationwide learn Council (NRC) boost guidance for setting up such degrees. according to that request, the NRC released directions for constructing neighborhood Emergency publicity degrees for dangerous elements in 1993. therefore, typical working strategies for constructing Acute publicity guide degrees for unsafe components used to be released in 2001, delivering up to date approaches, methodologies, and different guidance utilized by the nationwide Advisory Committee (NAC) on Acute publicity instruction degrees for unsafe ingredients and the Committee on Acute publicity guide degrees (AEGLs) in constructing the AEGL values. In 1998, EPA and DOD asked that the NRC independently overview the AEGLs constructed through NAC. based on that request, the NRC geared up inside its Committee on Toxicology (COT) the Committee on Acute publicity instruction degrees, which ready this file. Acute publicity instruction degrees for chosen Airborne chemical compounds is the 10th quantity of the sequence and files for N,N-dimethylformamide, jet propellant fuels five and eight, methyl ethyl ketone, perchloromethyl mercaptan, phosphorus oxychloride, phosphorus trichloride, and sulfuryl chloride.

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Necropsy was conducted on all base group rats, and most tissues from the control and high-concentration groups and the livers from rats from all base groups were examined histologically. In the cardiovascular group, blood pressure and electrocardiograms were taken within 24 h of the last DMF exposure, and the hearts of these animals were examined microscopically. In the renal function group, animals were placed in metabolism cages and urine collected for 16 h at the end of the study, and kidneys were collected at necropsy and evaluated histologically.

The DMF-exposed workers were compared with the referent group for history of chronic disease, findings at periodic health examinations, and sickness absenteeism over a 5-year period. Although all illnesses were investigated, the liver, gastrointestinal system, and cardiovascular system were of particular focus. Because differences were observed in the distribution of age and race among the DMF-exposed and the referent groups, comparisons were made by age categories and by computing age-adjusted rates.

27 N,N-Dimethylformamide Ten Crl:CD male rats inhaled DMF at 2,523 ppm for 6 h/day for 5 days (information about exposure chamber not provided) and were observed for 10 days following cessation of exposure (Kennedy and Sherman 1986). Animals were observed and weighed daily. Histopathologic examination was conducted on all rats either upon death or at the termination of the 10-day period. Clinical signs among exposed rats consisted of progressive weakness, discomfort, and body-weight loss. Seven rats died 1 to 3 days after the last exposure with evidence of dehydration and acute liver necrosis.

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