By Ole G. Mouritsen, Luis A. Bagatolli
The current e-book provides a multi-disciplinary standpoint at the physics of lifestyles and the actual function performed via lipids (fats) and the lipid-bilayer portion of mobile membranes. The emphasis is at the actual houses of lipid membranes visible as delicate and molecularly dependent interfaces. by way of combining and synthesizing insights bought from quite a few contemporary experiences, an try out is made to elucidate what membrane constitution is and the way it may be quantitatively defined. in addition, it's proven how organic functionality mediated via membranes is managed via lipid membrane constitution and association on size scales starting from the dimensions of the person molecule, throughout molecular assemblies of proteins and lipid domain names within the diversity of nanometers, to the dimensions of entire cells. functions of lipids in nanotechnology and biomedicine also are described.
The first variation of the current e-book used to be released in 2005 whilst lipidomics used to be nonetheless a great deal an rising technological know-how and lipids approximately to be famous as being as very important for all times as proteins, sugars, and genes. This considerably multiplied and revised version takes into consideration the large quantity of data received over the last decade. additionally, the ebook now contains extra educational fabric at the biochemistry of lipids and the rules of lipid self-assembly.
The ebook is aimed toward undergraduate scholars and younger examine employees inside physics, chemistry, biochemistry, molecular biology, meals, in addition to pharmaceutical and biomedical sciences.
From the stories of the 1st edition:
"This is a hugely fascinating ebook and a excitement to learn. It represents a brand new and ideal pedagogical creation to the sphere of lipids and the biophysics of organic membranes. I reckon that physicists and chemists in addition to biologists will make the most of this method of the sector and Mouritsen exhibits a deep perception into the actual chemistry of lipids." (Göran Lindblom, Chemistry
and Physics of Lipids 2005, vol. one hundred thirty five, web page 105-106)
"The ebook takes the reader on an exhilarating trip during the lipid global, and Mouritsen draws the eye with a full of life sort of writing … . a complete view of the ‘lipid sea’ should be simply accomplished, gaining the suitable views for envisaging destiny advancements within the nascent box of lipidomics." (Carla Ferreri, ChemBioChem, Vol. 6 (8), 2005)
Read Online or Download LIFE - AS A MATTER OF FAT: Lipids in a Membrane Biophysics Perspective PDF
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The current e-book provides a multi-disciplinary viewpoint at the physics of existence and the actual position performed by means of lipids (fats) and the lipid-bilayer portion of phone membranes. The emphasis is at the actual homes of lipid membranes visible as gentle and molecularly established interfaces. through combining and synthesizing insights acquired from a number of fresh reviews, an try is made to elucidate what membrane constitution is and the way it may be quantitatively defined.
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Additional resources for LIFE - AS A MATTER OF FAT: Lipids in a Membrane Biophysics Perspective
A Saturated hydrocarbon chain with 14 carbon atoms. b Mono-unsaturated hydrocarbon chain with 18 carbon atoms. , n is a prefix and x is the number of the carbon atom that participates in the first double bond counting from the methyl terminal end of the chain (ω; omega position). This nomenclature leads to the well-known ω-3 and ω-6 families of polyunsaturated fatty acids (see Sect. 1 for more details). Therefore, the lipid nomenclature for oleic acid is 18:1n9 (see Fig. 3). , the cis and trans versions of oleic acid).
The hydrophobic effect is accompanied by subtle changes in the ordering of the water dipole moments. In contrast to common belief, the water dipoles are more ordered near hydrophilic surfaces than hydrophobic surfaces. The higher degree of water ordering at hydrophilic surfaces implies a slowing down of the water diffusion along the interface. , the polymer Nafion) excluding latex microspheres (or fluorescent probes) up to a distance of 200 µm from the polymer surface. 6 Plucking Lipids 43 and liquid water.
The lipid bilayer in Fig. 4b can be considered as two monolayers back to back like in a skinny oil-in-water mixture (cf. Fig. 3d). Several lipid bilayers often organize among themselves to form multi-lamellar structures as shown in Fig. 4c. The forces that stabilize a stack of bilayers are of a subtle origin and will be dealt with in Sect. 3. Obviously, open ends cannot be tolerated, and the lipid bilayers have to close onto themselves and form closed objects as shown in Fig. 4e, f. Such structures are called respectively uni-lamellar and multi-lamellar lipid vesicles or liposomes.